Decoy substrate of O-GalNAc containing glycans (mucins)

Product ID: SV2498
Tags: Decoy substrate, Inhibitor, Mucin, N-Acetyl-Galactosamine
Product Price Estimated Shipping Time Purchase
BnGalNAc - 25 mg
125.00 1-3 days
BnGalNAc - 100 mg
325.00 1-3 days

Product information

  • Function

    BnGalNAc is a decoy substrate for the biosynthesis of O-linked glycans based on O-GalNAc. It can be used to inhibit the biosynthesis of membrane linked O-GalNAc containing glycans. Instead cells produce and excrete glycans attached to the BnGalNAc decoy substrate which can be analyzed with mass spectrometry. A more cell permeable and potent derivative of BnGalNAc called P-BnGalNAc is also available here.1

  • Mode of action

    O-linked glycans based on α-O-GalNAc residues starts with the addition of α-O-GalNAc residues to serine or threonine side chains. Next, additional sugars are added to the α-O-GalNAc residue. BnGalNAc is a cell permeable derivative of GalNAc. It enters cells and acts as a decoy substrate. Instead of adding monosaccharides to α-O-GalNAc glycoproteins, these residues are added to BnGalNAc. The corresponding glycoconjugates are excreted into the cell medium and the synthesis of mucins and other glycoconjugates based on α-O-GalNAc is inhibited.

  • Applications

    BnGalNAc has been used to study the role of mucins in colorectal cancers.23

  • Handling

    Handling instructions:
    BnGalNAc is soluble in water and PBS and added to cells in from a stock solution. Good priming/inhibition is achieved at 1mM concentration.

  • Chemical Information

    CAS No.: 3554-93-6
    SMILES: O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H](OCC2=CC=CC=C2)O[C@@H]1CO
    Chemical formula: C15H21NO6
    Molecular weight: 311.33
    Purity: > 95%
    Identity: 1H NMR
    Shipping temperature: 20°C
    Storage temperature: -20°C


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