Control compound for experiments utilizing galactosamine derivatives

Product ID: SV6542
Synonyms: Ac4GalNAc
Tags: Control compound, N-Acetyl-Galactosamine
Product Price Estimated Shipping Time Purchase
P-GalNAc - 10 mg
125.00 1-3 days
P-GalNAc - 25 mg
225.00 1-3 days
P-GalNAc - 100 mg
525.00 1-3 days

Product information

  • Function

    P-GalNAc is a control compound for labeling/inhibition experiments utilizing acetylated galactosamine derivatives P-GalNAc6Az, P-GalNAlk, P-GalNAz, P-GalNPoc

  • Mode of action

    P-GalNAc is taken up by cells via passive diffusion because this compound contains O-acetyl (OAc) groups. These groups make the molecule more lipophilic so that it can passively diffuse over mammalian cell membranes. Inside cells, these O-acetyl groups are removed via non-specific esterase releasing N-acetylgalactosamine and acetic acid. It is possible that at high concentrations, the released acetic acid or the partially acetylated intermediates are toxic. In addition, at high concentrations, non-specific reactions of acetylated precursors and cysteine residues have been observed.2 At low µM concentrations, these effects may be negligible but it is advisable to use a control compounds such as P-GalNAc. Finally, P-GalNAc may be used to boost intracellular GalNAc levels. It has for example been shown that P-Neu5Ac can be used to boost intracellular neuraminic acid levels.3

  • Applications

    Control compound for labeling/inhibition experiments utilizing acetylated glucosamine derivatives. P-GalNAc6Az, P-GalNAlk, P-GalNAz, P-GalNPoc

  • Handling

    P-GalNAc is soluble in a mixture of DMSO and PBS and is added to cell culture from a stock solution.

  • Chemical Information

    CAS No.: 76375-60-5
    SMILES: O=C(C)OC1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1
    Chemical formula: C16H23NO10
    Molecular weight: 389.35
    Purity: > 95%
    Identity: 1H NMR
    Shipping temperature: 20°C
    Storage temperature: 20°C


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