Control compound for experiments utilizing sialic acid derivatives

Product ID: SV3783
Synonyms: Ac5Neu5Ac, PNANA
Tags: Control compound, Neuraminic acid
Product Price Estimated Shipping Time Purchase
P-Neu5NAc - 100 mg
150.00 1-3 days
P-Neu5NAc - 500 mg
450.00 1-3 days
P-Neu5NAc - 1000 mg
650.00 1-3 days

Product information

  • Function

    P-Neu5Ac is a control compound for labeling/inhibition experiments utilizing acetylated neuraminic acid derivatives. P-Neu5Ac9Az, P-Neu5NAz, P-Neu5Ac3F

  • Mode of action

    P-Neu5Ac is taken up by cells via passive diffusion because this compound contains O-acetyl (OAc) groups. These groups make the molecule more lipophilic so that it can passively diffuse over mammalian cell membranes. Inside cells, these O-acetyl groups are removed via non-specific esterase releasing neuraminic acid and acetic acid. It is possible that at high concentrations, the released acetic acid or the partially acetylated intermediates are toxic. In addition, at high concentrations, non-specific reactions of acetylated precursors and cysteine residues have been observed.1 At low µM concentrations, these effects are likely negligible but it is advisable to use a control compounds such as P-Neu5Ac. Finally, P-Neu5Ac can be used to boost neuraminic acid levels. In particular the expression of GD2 was improved by the addition of P-Neu5Ac. 2

  • Applications

    Control compound for labeling/inhibition experiments utilizing acetylated neuraminic acid derivatives (P-Neu5Ac9Az,P-Neu5NAz, P-Neu5NAz, P-Neu5Ac3F).

  • Handling

    P-Neu5Ac is soluble in a mixture of DMSO and PBS and is added to cell culture from a stock solution.

  • Chemical Information

    CAS No.: 73208-82-9
    SMILES: O=C(OC)C1(OC(C)=O)C[C@H](OC(C)=O)[C@@H](NC(C)=O)[C@H]([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)O1
    Chemical formula: C22H31NO14
    Molecular weight: 533.47
    Purity: > 95%
    Identity: 1H NMR
    Shipping temperature: 20°C
    Storage temperature: 20°C


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